Basf Se Corporation

Duke University

Angela Hofhine

Joachim Dickhaut

Franz-Josef Braun

Paul Bernasconi

Steffen Groβ

Nancy B Rankl

Barbara Wedel

Ramani Kandasamy

Damian O' Brecht London

Scott Zitko

William D Tracey, Jr

Lixian Zhong

Yifan Xu

Gang Lu

Jason Caldwell

Lynn Stam

Thomas M Gurganus

Nancy Stearns

Mike Griswold

Allison Weaver

Jennifer Zink

Robert D Kirkton

Fae Malone

John Dorsch

Daniel Houtz

The present invention relates to polypeptides, preferably from(DmShaI) as target for insecticides.

Screening assay for insecticides

Methods for identifying a candidate compound with an ability to modulate cation transport through a transient receptor potential (TRP) channel in a cell are disclosed. The methods can include (a) providing a cell expressing a recombinant nucleic acid sequence encoding an transient receptor potential (TRP) channel gene product or a functional fragment or derivative thereof; (b) contacting the cell with the candidate compound; (c) comparing cation transport in the cell in the absence of the candidate compound with cation transport in the cell in the presence of the candidate compound; and (d) identifying a candidate compound through the comparing step that modulates cation transport in the cell through the transient receptor potential (TRP) channel. Also disclosed are nucleic acid and amino acid sequences for insect TRP channel gene products, antibodies that bind to the disclosed TRP channels, and recombinant host cells the include the disclosed biosequences.

Methods and compositions for the identification of insect repellent compounds

Growing community of inventors

Durham, NC, United States of America

Angela Hofhine