Cornell University

Sloan-kettering Institute for Cancer Research

Sabic Innovative Plastics IP B.v.

Other

General Electric Company

Sabic Global Technologies B.v.

Andrew A Burns

Ulrich B Wiesner

Jason S Lewis

Michelle S Bradbury

Steven M Larson

Oula Penate Medina

Sumeet Jain

Michael Teruki Takemori

Mark Allen Cheverton

Jeffrey Michael Ashe

Hooisweng Ow

Arunkumar Natarajan

Juha Virtanen

Matthew Jeremiah Misner

Matthew Frank Niemeyer

Ralf Lenigk

Pradeep Jeevaji Nadkarni

Timo J Toivanen

Otto Valtteri Pekander

Shantaram Narayan Naik

Nancy Cecelia Stoffel

Vicki Herzl Watkins

Vinodkumar Vasudevan

Azar Alizadeh

Thomas P Quinn

Sora Kim

Amitabh Bansal

Moitreyee Sinha

Kiran ArunKumar Puthamane

Robert Santala

Hoosweng Ow

Obi Aghogho

Vicki H Watkins

Michael T Takemori

The present invention provides a fluorescent silica-based nanoparticle that allows for precise detection, characterization, monitoring and treatment of a disease such as cancer. The nanoparticle has a range of diameters including between about 0.1 nm and about 100 nm, between about 0.5 nm and about 50 nm, between about 1 nm and about 25 nm, between about 1 nm and about 15 nm, or between about 1 nm and about 8 nm. The nanoparticle has a fluorescent compound positioned within the nanoparticle, and has greater brightness and fluorescent quantum yield than the free fluorescent compound. The nanoparticle also exhibits high biostability and biocompatibility. To facilitate efficient urinary excretion of the nanoparticle, it may be coated with an organic polymer, such as poly(ethylene glycol) (PEG). The small size of the nanoparticle, the silica base and the organic polymer coating minimizes the toxicity of the nanoparticle when administered in vivo. In order to target a specific cell type, the nanoparticle may further be conjugated to a ligand, which is capable of binding to a cellular component associated with the specific cell type, such as a tumor marker. In one embodiment, a therapeutic agent may be attached to the nanoparticle. To permit the nanoparticle to be detectable by not only optical fluorescence imaging, but also other imaging techniques, such as positron emission tomography (PET), single photon emission computed tomography (SPECT), computerized tomography (CT), bioluminescence imaging, and magnetic resonance imaging (MRI), radionuclides/radiometals or paramagnetic ions may be conjugated to the nanoparticle.

Multimodal silica-based nanoparticles

A system for monitoring medical conditions includes a conformable medical monitoring device that includes a first substrate layer, which includes an electronics module, many signal traces, and at least one electrode, such that one or more of the many signal traces electrically couple the at least one electrode to the electronics module. The conformable medical monitoring device includes a second substrate layer positioned over the electronics module, the first substrate layer, or any combination thereof to insulate the electronics module, the first substrate layer, or any combination thereof. The conformable medical monitoring device also includes a third substrate layer positioned over the second substrate layer, such that the third substrate layer reduces electromagnetic interference caused by a voltage pulse and includes an adjustable system coupled to the first substrate layer and that changes a position of the at least one electrode relative to the electronics module.

Systems and methods for shielded and adjustable medical monitoring devices

Fluorescent silica-based nanoparticles

The present invention provides a fluorescent silica-based nanoparticle that allows for precise detection, characterization, monitoring and treatment of a disease such as cancer The nanoparticle has a fluorescent compound positioned within the nanoparticle, and has greater brightness and fluorescent quantum yield than the free fluorescent compound To facilitate efficient urinary excretion of the nanoparticle, it may be coated with an organic polymer, such as polyethylene glycol) (PEG) The small size of the nanoparticle, the silica base and the organic polymer coating minimizes the toxicity of the nanoparticle when administered in vivo The nanoparticle may further be conjugated to a ligand capable of binding to a cellular component associated with the specific cell type, such as a tumor marker A therapeutic agent may be attached to the nanoparticle Radionuclides/radiometals or paramagnetic ions may be conjugated to the nanoparticle to permit the nanoparticle to be detectable by various imaging techniques.

Articles for recording a holographic image are described. The articles include a holographic recording medium having a plurality of surfaces, having a transparent polymeric binder and a photochemically active dye, the holographic recording medium having a holographic image recorded therein formed by exposed areas of the photochemically active dye and unexposed areas of the photochemically active dye; and a first light-blocking layer or material over a first surface of the holographic recording medium from which surface the holographic image is viewed, the light blocking layer or material absorbing light in the wavelength range to which the photochemically active dye is sensitive and allowing transmission of light in a different wavelength range for viewing the holographic image.

Method of making holographic storage medium

A method of making a hologram includes recording a first hologram in a holographic recording medium at a first deformation ratio; changing the first deformation ratio to a second deformation ratio that is different from the first deformation ratio; and recording a second hologram in the holographic recording medium at the second deformation ratio to form a recorded holographic medium.

Complex holograms, method of making and using complex holograms

A method is described for recording a volume reflection holographic image that is viewable when illuminated by light at a wavelength W. The method includes

Reflection hologram storage method

A method of manufacturing an article for display of a holographic image is described that includes thermally fusing a holographic recording medium containing a photochemically active dye dispersed in a transparent thermoplastic polymer binder to another layer or material; and then exposing the holographic film to intersecting beams of coherent light to form a holographic image therein formed by photoreacted areas of the photochemically active dye and unreacted areas of the photochemically active dye.

Method of making holographic recording materials and articles formed thereby

A method of recording a volume holographic image is described in which a holographic recording medium containing a photoreactive dye is exposed to a plurality of coherent light sources emitting at a wavelength to which the dye is sensitive, thereby forming an interference fringe pattern therein. The photoreaction occurring in the areas of constructive interference generates a periodic array of photoreacted areas of the dye and unreacted areas of the dye. This generated interference fringe pattern may contain, but does not have to contain any image or other encoded information. Selected areas of the interference fringe pattern are then exposed to actinic radiation in such a manner to partially or fully bleach, remove, or deactivate the photoreactive dye fringe pattern, thereby producing a holographic pattern, shape, or image formed by areas of the interference fringe pattern that were not bleached, removed, or deactivated.

Holographic storage method

Growing community of inventors

Schenectady, NY, United States of America

Andrew A Burns