Glycom A/s

Andreas Schroven

Gyula Dekany

Markus Jondelius Hederos

Markus Hederos

Lars Kröger

Christoph Röhrig

Julien Boutet

Piroska Kovács-Pénzes

Ioannis Vrasidas

Christian Risinger

Ferenc Horváth

Károly Ágoston

Ágnes Ágoston

Elise Champion

István Bajza

Ignacio Pérez Figueroa

Sándor Demkó

Gergely Pipa

Péter Trinka

Johan Olsson

Gyula Dékany

Istvan Bajza

Ignacio Figueroa Pérez

László Kalmár

Peter Erdmann

Marie Bøjstrup

Andrea Schwarz

Ferenc Horvàth

Ignacio Figueroa-Pérez

Gábor Kádár

Sándor Demkò

Krisztián Kovàcs

Ágnes Jànosi

Irme Kovács

Ignacio Figuero-Pérez

Mette Fanefjord

Imre Kovács

Gyula DÉKANY

The present application discloses a method for enhancing the stability of a human milk oligosaccharide (HMO) or a HMO precursor or a HMO blend when stored for extended periods at temperatures above 25&#xb0; C. by spray-drying an aqueous solution of the HMO or HMO precursor to remove at least 90% of the water and providing a HMO or a HMO precursor or a HMO blend with a specific glass transition temperature. Also disclosed is a method for removing organic solvent residues from a human milk oligosaccharide (HMO) or a HMO precursor or a HMO blend by spray drying. Also disclosed is a method of enhancing the bioavailability of a human milk oligosaccharide (HMO) or a HMO precursor or a HMO blend by spray drying.

Enhancing the stability and purity and increasing the bioavailability of human milk oligosaccharides or precursors or blends thereof

A method of diversification of human milk oligosaccharides (HMOs) or precursors thereof, compounds obtainable by the method, and uses and compositions involving such compounds. The method comprises a) providing at least one compound or a mixture of the compounds selected from the group consisting of: optionally sialylated and/or fucosylated lactose derivatives of general formula 2 and salts thereof; b) adding at least one enzyme comprising a transglycosidase activity to the at least one compound or a mixture of compounds provided according to step a); and c) incubating the mixture obtained according to step b).

Diversification of human milk oligosaccharides (HMOs) or precursors thereof

The present invention relates to a method for preparation of the trisaccharide 6'-O-sialyllactose (formula (I)) or salts thereof as well as intermediates in the synthesis and for the use of 6&#x2032;-O-sialyllactose salts in pharmaceutical or nutritional compositions. 

Production of 6'-O-sialyllactose and intermediates

A method for generating human milk oligosaccharides (HMOs) or precursors thereof, compounds obtainable by the method, and uses and compositions involving such compounds. The method comprising the steps of a) providing at least one donor selected from the group of compounds of any of formulae 5 to 10, b) providing at least one acceptor from a group of lactose, LNT, LNnT and derivatives thereof, c) providing at least one enzyme comprising a transglycosidase activity and/or a glycosynthase activity, d) preparing a mixture of the at least one donor, at least one acceptor and at least one enzyme provided in steps a), b) and c); and e) incubating the mixture prepared according to step d).

Method for generating human milk oligosaccharides (HMOs) or precursors thereof

The invention relates to a method for the synthesis of compounds of general formula (1A) and salts thereof wherein one of the R groups is an &#x3b1;-sialyl moiety and the other is H, Xrepresents a carbohydrate linker, A is a D-glucopyranosyl unit optionally substituted with fucosyl, Ris a protecting group that is removable by hydrogenolysis, the integer m is 0 or 1, by a transsialidation reaction.

Synthesis of sialooligosaccharide derivatives

The present invention relates to an improved synthesis of a trisaccharide of the formula (1), novel intermediates used in the synthesis and the preparation of the intermediates. 

Method for the synthesis of a trisaccharide

The present invention relates to a method for preparation of the tetrasaccharide lacto-N-neotetraose (LNnt, formula (I)) especially in large scale, as well as intermediates in the synthesis, a new crystal form (polymorph) of LNnt, and the use thereof in pharmaceutical or nutritional compositions. 

Method for preparation of the tetrasaccharide lacto-N-neotetraose (LNnt) containing N-acetyllactosamine

The present invention relates to an improved synthesis of a trisaccharide of the formula, novel intermediates used in the synthesis and the preparation of the intermediates. 

The present application discloses a method for the crystallization of fucose, characterized in that the crystallization is carried out from a mixture comprising fucose and at least one 6-deoxy sugar selected from 6-deoxy-talose and 6-deoxy-gulose. In one embodiment, the mixture comprises fucose and 6-deoxy-talose.

Method for crystallization of fucose

The present invention relates to novel polymorphs of the trisaccharide 2'-O-fucosyllactose (2-FL) of formula (1), methods for producing said polymorphs and their use in pharmaceutical or nutritional compositions. 

Polymorphs of 2'-O-fucosyllactose and producing thereof

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Barssel, Germany

Andreas Schroven