Kaohsiung Medical University

University of California

Georgia Tech Research Corporation

An-Shen Lin

Yang-Chang Wu

Fang-Rong Chang

Chin-Chung Wu

Suh-Hang Hank Juo

Ying-Chi Du

Kuo-Hsiung Lee

Tusty-Jiuan Hsieh

Julia M Kubanek

Karine G Le Roch

E Paige Stout

Amy L Lane

Mark E Hay

Disclosed are a composition for preventing and treating atherosclerosis which includes chalcone compound. In particular, the chalcone compound bound with 2-hydroxyl in ring A and 4'-methyoxy in ring B has versatile therapeutic potentials on anti-atherosclerosis by acting as PPAR&#x3b3; inducer, p44/42 MAPK inhibitor and cell cycle blocker and does not show toxicity to human aortic smooth muscle cells (HASMCs). In addition, the chalcone compound exhibits synergistic effect with the PPAR&#x3b3; ligand (rosiglitazone) to inhibit cell proliferation and the upregulation of cyclin D1, cyclin D3, interleukin-1&#x3b2; (IL-1&#x3b2;) and interleukin-6 (IL-6) induced by oxidized low density lipoprotein (Ox-LDL).

Composition for treating atherosclerosis and a preparation method thereof

Provided herein compounds, compositions and methods useful for the treatment of malaria for a subject in need thereof, including compounds of Formula (I), Formula (II), Formula (III), Formula (IV), and Formula (V).

Compounds and compositions useful in the treatment of malaria

A composition for treating cancer cells and a preparation method therefor are provided. The novel flavonoid compounds are obtained from natural plants, and more particularly the compounds have a cytotoxicity on cancer cells.

Composition for treating cancer cells and preparation method for the same

A pharmaceutical composition having a cytotoxic effect to a cancer cell is provided. The pharmaceutical composition includes a flavonoid compound having a formula as wherein B ring is a 4-oxo-cyclohexa-2,5-dienyl group, and any one of R-Ris one selected from a group consisting of hydrogen group, hydroxyl group, C1-C20 alkyl group, C1-C20 ether group, C1-C20 ester group, carboxyl group, halogen and sugar. The flavonoid compound is obtained from a chemical method being one of a total synthesis method and a semi-synthesis method.

Composition for treating cancer cells and synthetic method for the same

Growing community of inventors

Kaohsiung, Taiwan

An-Shen Lin