Micro Vesicular Systems, Inc.

An-Cheng Chang

Donald F Wallach

Rajiv Mathur

S Esmail Tabibi

The present invention features a method of making lipid vesicles and the lipid vesicles themselves made from monomeric and dimeric alkyds. These alkyds are esters made as a condensation product of a first reactant having at least one free hydroxyl group and a C.sub.12 -C.sub.20 fatty acids chain and a second reactant which is an aromatic acid chloride or anhydride. Preferred first reactants are esters of polyols and C.sub.12 -C.sub.20 fatty acids, ethers of polyols and C.sub.12 -C.sub.20 fatty acids, and C.sub.12 -C.sub.20 fatty alcohols.

Lipid vesicles having an alkyd as a wall-forming material

A new controlled release vehicle which acts by breakdown of the entrapping material upon hydration has been developed. The preferred release vehicle is made of a carboxylated cellulose, e.g., carboxymethylcellulose, which is treated with a cross-linking agent such as aluminum ions and, preferably, a hydrophobicity agent such as acetic acid. The vehicle is broken down by a release agent, e.g., cellulase, which may be coated on the vehicle together with a coating agent, e.g., hydroxypropylcellulose. The vehicle is dried, entrapping the molecular to be entrapped, e.g., an enzyme, and hydration activates the cellulase which breaks down the carboxymethylcellulose, releasing the entrapped molecular.

Controlled release vehicle

The present invention features methods of making absorbent material which exhibit excellent absorption for saline and other liquids as well as being biodegradable. The methods of the invention form a particulate which can be stored in dry form and rehydrated at any time. The particulate can be used to replace the presently utilized polyacrylate superabsorbers. The base material used in the methods of the invention is a carboxylated cellulosic material such as carboxymethylcellulose, preferably, a carboxymethylcellulose having a DS, or Degree of Substitution, of 0.5 or greater. The carboxylated cellulose material is reacted with two distinct agents; a cross-linking agent and a hydrophobicity agent to make the final absorbent.

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Nashua, NH, United States of America

An-Cheng Chang