Council of Scientific and Industrial Research

Amrit Raj Ghosh

Ayan Mukherjee

Arindam Talukdar

Dipyaman Ganguly

Biswajit Kundu

Barnali Paul

Oindrila Rahaman

Swarnali Roy

Shounak Roy

Roopkatha Bhattacharya

The present invention relates to small molecule 4-(piperazin-1-yl)quinazolin-2-amino compounds with formula (I) useful for inhibiting signalling by certain toll-like receptors (TLRs), especially TLR9. Toll-like receptors (TLRs) are members of the larger family of evolutionarily conserved pattern recognition receptors which are critical first line of defense for self-nonself discrimination by the host immune response. Aberrant TLR9 activation is implicated in autoreactive inflammation in different autoimmune diseases. The invention depicts compounds with formula (I), composition and methods can be used in a number of clinical applications, including as pharmaceutical agents and methods for treating conditions involving unwanted immune activity due to TLR9 activation. 

Blocking toll-like receptor 9 signaling with small molecule antagonist

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Jadavpur, India

Amrit Raj Ghosh