The United States of America as Represented by the Secretary of

The United States of America, as Represented by the Secretary, Department of Health and Human Services

The United States of America as Represented by the Department of Health

Allen M Spiegel

Lance A Liotta

Francis S Collins

Michael R Emmert-Buck

Zhengping Zhuang

Irina A Lubensky

Larisa V Debelenko

Sunita K Agarwal

Settara Chandrasekharappa

A Lee Burns

Siradanahalli Guru

Stephen J Marx

Pachiappan Manickam

The invention relates to the discovery of a novel tumor suppressor gene which is associated with multiple endocrine neoplasia type 1. The gene has been designated MEN1 and the gene product is menin. The absence of this protein and associated mutations in the corresponding gene have been identified in individuals suffering from multiple endocrine neoplasia type 1. The identification of this marker for multiple endocrine neoplasia type 1 has diagnostic uses as well as for gene therapy.

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Antibodies having binding specificity for a peptide having the sequence ANNLRGCGLY have been prepared. The antibodies bind to the GTP-binding protein G.sub.o and are useful for identifying, isolating and distinguishing between different GTP binding proteins.

Antibody reagents that identify the carboxy-terminal peptide of the

Antibodies which bind to a peptide having the sequence KENLKDCGLF, which represents the C-terminal decapeptide of the GTP-binding protein transducin-.alpha., are described. Binding to transducin-.alpha. by peptide-specific antiserum AS/7 is not affected by pertussis toxin-catalyzed ADP-ribosylation.

Antibody reagents that specifically bind to the carboxyl-terminal

Substantially pure, synthetic peptides corresponding to specific epitopic sites of various G-proteins and antibodies having binding affinity specifically for said epitopic sites have been prepared. Kit and method for identifying various G-proteins are also disclosed.

Reagents and probes for distinguishing and isolating different

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Bethesda, MD, United States of America

Allen M Spiegel