Smithkline Beecham Corporation

Alison Francis Chalker

Karen Anne Ingraham

David John Holmes

Magdalena Zalacain

Sanjoy Biswas

Richard Lloyd Warren

James Raymond Brown

Chi Young So

Martin Karl Russel Burnham

Thomas B Mathie

Christopher Michael Traini

Patrick Vernon Warren

Stephanie Van Horn

Min Wang

Deborah Dee Jaworski

Damien McDevitt

Jennifer E Ray

Marie J Mazzulla

Chi Yong So

Michael Arthur Lonetto

Nicola Gail Wallis

Martin Karl Burnham

David John Payne

Christine Marie Debouck

Jeffrey L Mooney

Stewart Campbell Pearson

David William Holden

Anna Lisa Kosmatka

John Peter Throup

Yi Yi Zhong

Martin K R Burnham

Earl William May

Richard L Warren, Jr

Alexander Philip Bryant

Anna Lisa Lenox

Andrea Marra

Lisa K Shilling Katz

Gee W Lau

Sauli J Haataja

Jun Yu

The invention provides infB polypeptides and polynucleotides encoding infB polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing in polypeptides to screen for antibacterial compounds.

inFB

The invention provides trmA methyl transferase (trmD) polypeptides and polynucleotides encoding trmD polypeptides and methods for producing such polypeptides by recominant techniques from strepococcus pneumoniae. Also provided are methods for utilizing polypepides to screen for antibacterial compounds.

trmD

The invention provides FabG polypeptides and polynucleotides encoding FabG polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing FabG polypeptides to screen for antibacterial compounds.

Nucleic acids encoding Streptococcus pneumoniae FabG

The invention provides yhxB polypeptides and polynucleotides encoding yhxB polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing yhxB polypeptides to screen for antibacterial compounds.

yhxB

The invention provides tktA polypeptides and polynucleotides encoding tktA polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing tktA polypeptides and polynucleotides to screen for antibacterial compounds and for the detection of

TktA from Streptococcus pneumoniae

The invention provides ytgP polypeptides and polynucleotides encoding ytgP polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing ytgP polypeptides to screen for antibacterial compounds.

ytgP

The invention provides kdtB polypeptides and polynucleotides encoding kdtB polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing kdtB polypeptides to screen for antibacterial compounds.

kdtB

The invention provides tdk polypeptides polynucleotides encoding tdk polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing tdk polypeptides to screen for antibacterial compounds.

The invention provides ndp polypeptides and polynucleotides encoding ndp polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing ndp polypeptides to screen for antibacterial compounds.

Isolated nucleic acid encoding nucleotide pyrophosphorylase

The invention provides nadE polypeptides and polynucleotides encoding nadE polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing nadE polypeptides to screen for antibacterial compounds.

nadE from Streptococcus pneumoniae

The invention provides nusB polypeptides and polynucleotides encoding nusB polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing nusB polypeptides to screen for antibacterial compounds.

nusB polypeptides and polynucleotides and methods thereof

The invention provides yfjO polypeptides and polynucleotides encoding yfjO polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing yfjO polypeptides to screen for antibacterial compounds.

tRNA methyltransferase from Streptococcus pneumoniae

The invention provides metK polypeptides and polynucleotides encoding metK polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing metK polypeptides to screen for antibacterial compounds.

metK from Streptococcus pneumoniae

The invention provides murF2 polypeptides and polynucleotides encoding murF2 polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing murF2 polypeptides to screen for antibacterial compounds.

murF2

The invention provides DnaB polypeptides and polynucleotides encoding DnaB polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing DnaB polypeptides to screen for anibacterial compounds.

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Trappe, PA, United States of America

Alison Francis Chalker