The Ohio State University

Albert H Soloway

Werner Tjarks

Rolf F Barth

Abul K Anisuzzaman

Fazlul Alam

Feng-Guang Rong

Iwona M Wyzlic

The invention relates to novel boron-containing nucleosides and amino acids which can utilize the enzymatic systems in tumor cells for incorporating such boron-containing structures into nucleic acids and proteins. Subsequent use of boron neutron capture therapy provides a method for treating tumor cells.

Carboranyl uridines and their use in boron neutron capture therapy

There is disclosed a process for preparing carboranyl uridine nucleoside compounds and their diethyl ether adducts, which exhibit a tenfold increase in boron content over prior art boron containing nucleoside compounds. Said carboranyl uridine nucleoside compounds exhibit enhanced lipophilicity and hydrophilic properties adequate to enable solvation in aqueous media for subsequent incorporation of said compounds in methods for boron neutron capture therapy in mammalian tumor cells.

2' and 3' Carboranyl uridines and their diethyl ether adducts

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Worthington, OH, United States of America

Albert H Soloway