The United States of America, As Represented by the Secretary, Department of Health and Human Services

Alan O Perantoni

Nadya Tarasova

Christopher J Michejda

C Andrew Stewart

Vadim Gaponenko

Sergey G Tarasov

Olga Timofeeva

Giorgio Trinchieri

Howard A Young

Marco A Cardone

Shunsuke Tanigawa

Nadya I Tarasova

A peptide or peptidomimetic comprising the amino acid sequence of the second helix of a STAT protein, or a variant of such sequence, wherein the peptide or peptidomimetic comprises about 40 or fewer amino acids and binds to a STAT protein, as well as a method of inhibiting a STAT protein in a cell, a method of treating or preventing a disease associated with STAT overexpression in a host, and related compounds, compositions, and methods.

Peptide-based stat inhibitor

A peptide or peptidomimetic comprising an amino acid sequence based on conserved regions of IL10 or IFN-gamma receptor sequences, and related compounds and compositions, as well as methods for the use thereof to inhibit cytokine signaling.

Peptide-based inhibitor of interleukin-10 or interferon-gamma signaling

A peptide or peptidomimetic comprising the amino acid sequence KKRLSVXLTSSLFR (SEQ ID NO: 1) or the inverse thereof, or comprising at least eight contiguous amino acids of helix C of &#x3b2;-catenin (SEQ ID NO: 41) or inverse thereof, wherein the peptide or peptidomimetic comprises a total of about 50 or fewer amino acids and inhibits the Wnt pathway, as well as a method of inhibiting the Wnt pathway in a cell, a method of treating or preventing a disease mediated by the Wnt pathway, and related compounds, compositions, and methods.

Synthetic peptide inhibitors of Wnt pathway

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Fairfield, PA, United States of America

Alan O Perantoni