Shionogi Company Limited

Akira Mashimo

Shunji Ichio

Yoshinori Tamura

Kouichi Noguchi

Satoshi Sakuma

Hiroshi Ueda

Hiroshi Murazato

The solid preparation which improved the dissolution profile and the stability of the 6,7-unsaturation-7-carbamoyl morphinan derivative is provided. When 6,7-unsaturation-7-carbamoyl morphinan derivative, croscarmellose sodium and ferric oxide were contained, not titanium oxide in the solid preparations and the coating solid preparations, a dissolution rate after 15 minutes of the dissolution test is more than 85%, and stability, particularly, light stability can be improve.

Preparation containing 6,7-unsaturated-7-carbamoyl morphinan derivatives

The present invention offers the manufacturing method of the solid formulation wherein the standard deviation of the active ingredient content in the solid formulation becomes 5% or less by mixing the excipients which have a median particle size of 15 or more times, preferably 20 times or more to the median particle size of an active ingredient.

Manufacturing process of formulation having improved content uniformity

The present invention relates to solubility improving preparation for enhancing the oral absorption of a poorly soluble drug, which is comprising (A) and (B);

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Osaka, Japan

Akira Mashimo