Otsuka Pharmaceutical Factory, Inc.

Hoxan Corporation

Akio Kawamura

Yasuo Kuraoka

Nobuo Sakao

Hiroshi Kamogawa

Motoki Yonekawa

Yoshimi Nakanishi

Yoichi Kasai, Deceased

Toshihiko Tsuburaya

Akira Kakita

Eiji Sakashita

Osamu Kaneko

Method of washing secondary filter in process for filtering plasma

In a process for filtering plasma by separating blood into blood cells and plasma by a primary filter and filtering the separated plasma by a secondary filter to remove macromolecules from the plasma as harmful components, the loss of plasma to be discarded from the system by a procedure for eliminating plugging of the secondary filter can be diminished by opening an inner chamber of the secondary filter to the atmosphere to thereby lower the internal pressure of the chamber every time increase of the pressure to an upper limit value due to an increasing plugging tendency of the secondary filter is detected, and washing the interior of the secondary filter from the inner and outer chamber sides after the internal pressure has lowered.

Apparatus for filtering plasma

A method of fabricating frozen fine liver pieces for an artificial liver which comprises cutting a liver removed from a human being or an animal, from which blood is removed into fine pieces of square shape and freezing the liver pieces with helium gas. A freezing apparatus for an artificial liver which has gas phase pressurizing means for pressurizing liquid helium coupled to a chamber for storing the liquid helium, a helium gas conduit dipped in the liquid helium passed through the chamber to be closed and contained, in which the liver fine pieces are telescopically received and an exhaust conduit provided with a control valve coupled to the freezing chamber. And, a freezing vessel for an artificial liver which has a flow conduit capable of being coupled to an upper portion and a lower portion of a unit, an upper coupling port and a lower coupling port respectively formed therethrough with closing plugs, two or more mesh plates laterally laid elevationally in the unit, and exit opening in to a containing chamber thus formed.

Method of fabricating frozen fine liver piece for artificial liver,

A method of fabricating frozen fine liver pieces for an artificial liver which comprises cutting a liver removed from a human being or an animal, from which blood has been removed, into fine pieces of square shape and freezing the liver pieces with helium gas. A freezing apparatus for an artificial liver which has gas phase pressurizing means for pressurizing liquid helium coupled to a chamber for storing the liquid helium, a helium gas conduit dipped in the liquid helium passed through the chamber to be closed and contained, to which the liver fine pieces are telescopic, and an exhaust conduit provided with a control valve coupled to the freezing chamber. And, a freezing vessel for an artificial liver which has a flow conduit capable of being coupled to an upper portion and a lower portion of a unit, an upper coupling port and a lower coupling port respectively formed therethrough to close plugs, two or more mesh plates laterally laid elevationally in the unit, an exit opened corresponding to a containing chamber thus formed.

Method of fabricating frozen fine liver pieces for artificial liver,

Growing community of inventors

Sapporo, Japan

Akio Kawamura