Mitsubishi Materials Corporation

Other

Yoshida Pharmaceutical Co., Ltd.

Akihiro Nakamura

Akira Nishihara

Tsunetoshi Honda

Maki Takizawa

Michio Harada

Shigehiro Arakawa

A hydrophobic silica powder, treated with an amino-substituted silane compound represented by the formula (1) and an organopolysiloxane, having an amount of triboelectrification relative to iron of from over +100 .mu.C/g to up to +700 .mu.C/g, and a hydrophobing ratio of at least 60% as measured by the transmittance method:

Hydrophobic silica powder, manufacturing method thereof and developer

A novel disinfectant is disclosed. Said disinfectant is a compound 1,n-bis(N.sup.5 -m-, or p-trifluoromethyl-phenyl-N.sup.1 -biguanido)-C.sub.3 -C.sub.10 -alkane. The m-trifluoro-C.sub.6 derivative is a known compound. The compounds of the present invention exhibit germicidal effect against Pseudomonas aeruginosa, Proteus vulgaris and Alcaligenes faecalis at concentrations of 1/4-1/8 of the effective concentration for chlorhexidine. Against other microorganisms, the compounds are effective at the same level as chlorhexidine.

Method for disinfection using a 1,n-bis(N.sup.5

A novel bis-biguanide compound suitable for use as a disinfectant has the following formula: ##STR1## where n is an integer from 2 to 10 inclusive. A pharmaceutically acceptable salt, particularly gluconate salt of the compound is also useful as a disinfectant. The bis-biguanide compound has germicidal activities comparable to those of widely used chlorhexidine with respect to width of antibacterial spectrum and is superior to chlorhexidine in immediate effectiveness. It exhibits excellent germicidal activities against Pyocyaneus bacilli, on which chlorhexidine has poor effect.

Bis-biguanide compound useful as a disinfectant

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Omiya, Japan

Akihiro Nakamura