T.o.p. (transgenic Operative Products) S.r.l.

Euticals Spa

Adriana Caterina Maggi

Paolo Ciana

Mario Brufani

Barbara Garofalo

Luisa Maria Migneco

Rinaldo Marini Bettolo

Luigi Filocamo

Paolo Maria Farina

Roberta Joudioux

Francesca Ceccacci

Gillian Ashcroft

The object of the invention is a method for the production of a non-human transgenic mammal by means of which it is possible to monitor in vivo and in all the tissues the state of activation of any intracellular receptor, utilizing a reporter gene inducible by natural or synthetic molecules which modulate the activity of such receptor. The mammal is question is preferably a mouse.

Transgenic mouse for screening and for studies of the pharmacodynamics and pharmacokinetics of ligands acting on the oestrogen receptor and its intracellular receptors, and method for the preparation thereof

The invention relates to 17&#x3b1;-(5-hydroxy-C-hydrocarbyl)-1,3,5(10)-estratrien-3,17&#x3b2;-diol derivatives having cicatrising activity, preferably for topical use on wounds, without significant systemic effects, and to pharmaceutical compositions containing them. In particular, the invention relates to estradiol 17&#x3b1;-(5-hydroxypentyn-1-yl)derivatives and 3-esters, 5'-esters and 3,5&#x2032;-diesters thereof and to a process for the preparation thereof by reaction of 3-OR-protected estrone with an alkali metal derivative of OR-protected 5-pentynol, followed by 3-, 5-&#x2032; or 3,5&#x2032;-esterif&#xca;cation.

17-alpha-substituted derivatives of estradiol with wound-healing activity

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Milan, Italy

Adriana Caterina Maggi