The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 14, 2025
Filed:
Jun. 04, 2021
Applicant:
Sanbio, Inc., Mountain View, CA (US);
Inventor:
Casey C. Case, San Mateo, CA (US);
Assignee:
SanBio, Inc., Oakland, CA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 5/079 (2010.01); C12N 5/0775 (2010.01); C12Q 1/6881 (2018.01); C12Q 1/6883 (2018.01);
U.S. Cl.
CPC ...
C12N 5/0618 (2013.01); C12N 5/0663 (2013.01); C12Q 1/6881 (2013.01); C12Q 1/6883 (2013.01); C12N 2501/42 (2013.01); C12N 2506/1353 (2013.01); C12N 2510/00 (2013.01); C12Q 2600/156 (2013.01);
Abstract
Disclosed herein are cells, that are descendents of marrow adherent stem cells (MASCs), capable of rescuing and/or reversing various neural disorders after transplantation into sites of central nervous system (CNS) or peripheral nervous system (PNS) injury. The cells contain alterations in the methylation state of certain genes, compared to their methylation state in MASCs. Methods of making cells capable of rescuing and/or reversing various neural disorders after transplantation into sites of CNS or PNS injury, by alteration of the methylation status of certain genes, are also provided.