The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jul. 23, 2024

Filed:

Mar. 19, 2022
Applicant:

Myokardia, Inc., Brisbane, CA (US);

Inventors:

Johan Oslob, Sunnyvale, CA (US);

Robert Anderson, Brisbane, CA (US);

Danielle Aubele, San Mateo, CA (US);

Marc Evanchik, Boulder, CO (US);

Jonathan Charles Fox, San Francisco, CA (US);

Brian Kane, San Mateo, CA (US);

Puping Lu, Foster City, CA (US);

Robert McDowell, San Francisco, CA (US);

Hector Rodriguez, San Bruno, CA (US);

Yonghong Song, Foster City, CA (US);

Arvinder Sran, Fremont, CA (US);

Assignee:

MyoKardia, Inc., Brisbane, CA (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/513 (2006.01); A61K 45/06 (2006.01); C07D 239/545 (2006.01); C07D 239/553 (2006.01); C07D 401/04 (2006.01); C07D 401/12 (2006.01); C07D 403/04 (2006.01); C07D 403/12 (2006.01); C07D 405/04 (2006.01); C07D 405/12 (2006.01); C07D 413/04 (2006.01); C07D 413/12 (2006.01);
U.S. Cl.
CPC ...
A61K 31/513 (2013.01); A61K 45/06 (2013.01); C07D 239/545 (2013.01); C07D 239/553 (2013.01); C07D 401/04 (2013.01); C07D 401/12 (2013.01); C07D 403/04 (2013.01); C07D 403/12 (2013.01); C07D 405/04 (2013.01); C07D 405/12 (2013.01); C07D 413/04 (2013.01); C07D 413/12 (2013.01);
Abstract

Provided are novel pyrimidine dione compounds and pharmaceutically acceptable salts thereof, that are useful for the treatment of hypertrophic cardiomyopathy (HCM) and conditions associated with left ventricular hypertrophy or diastolic dysfunction. The synthesis and characterization of the compounds and pharmaceutically acceptable salts thereof, are described, as well as methods for treating HCM and other forms of heart disease.


Find Patent Forward Citations

Loading…