The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 15, 2023
Filed:
Dec. 02, 2020
Inozyme Pharma, Inc., Boston, MA (US);
Anthony Quinn, Chestnut Hill, MA (US);
Nelson Hsia, Cambridge, MA (US);
Tayeba Khan, Lexington, MA (US);
Kim Lynette Askew, Lincoln, MA (US);
Gregory Grabowski, Lexington, MA (US);
Zhiliang Cheng, New Haven, CT (US);
W. Charles O'Neill, Decatur, GA (US);
Inozyme Pharma, Inc., Boston, MA (US);
Abstract
The present invention provides a method of treating NPP1 deficiency or NPP1-associated disease such as idiopathic infantile arterial calcification (IIAC), pseudoxanthoma elasticum, vascular calcification in chronic kidney disease (VCCKD), insulin resistance, hypophosphatemic rickets, myocardial ischemia, joint calcification, angioid streaks, and ossification of the posterior longitudinal ligament of the spine. The present invention provides a method for treating tissue calcification by administering soluble NPP1 to produce a transient increase in serum pyrophosphate levels.