The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 27, 2023
Filed:
Oct. 01, 2019
Applicant:
Thomas Jefferson University, Philadelphia, PA (US);
Inventors:
Andrzej Fertala, Voorhees, NJ (US);
Andrzej Steplewski, Phoenixville, PA (US);
Assignee:
Thomas Jefferson University, Philadelphia, PA (US);
Primary Examiner:
Int. Cl.
CPC ...
C07K 16/00 (2005.12); C07K 16/18 (2005.12); C07K 16/28 (2005.12); C07K 16/46 (2005.12); A61K 39/00 (2005.12);
U.S. Cl.
CPC ...
C07K 16/18 (2012.12); A61K 2039/505 (2012.12); C07K 2317/24 (2012.12); C07K 2317/565 (2012.12); C07K 2317/622 (2012.12); C07K 2317/76 (2012.12); C07K 2317/92 (2012.12);
Abstract
A chimeric, humanized or single-chain antibody contains a light chain variable region containing the complementarity determining regions of SEQ ID NO: 1, SEQ ID NO:2 and SEQ ID NO:3, and a heavy chain variable region containing the complementarity determining regionsSEQ ID NO:4,SEQ ID NO:5 and SEQ ID NO:6. The antibody or antibody fragment thereof is capable of binding the C-terminal telopeptide of the α2(I) chain of human collagen I, and is useful in the treatment of diseases or disorders associated with excessive collagen fibril.