The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 10, 2022
Filed:
Sep. 18, 2019
Nitto Denko Corporation, Osaka, JP;
Yoshiro Niitsu, Hokkaido, JP;
Kenjirou Minomi, Osaka, JP;
Bharat Majeti, San Diego, CA (US);
Li Wang, San Diego, CA (US);
Jihua Liu, San Marcos, CA (US);
Roger Adami, Carlsbad, CA (US);
Wenbin Ying, San Diego, CA (US);
NITTO DENKO CORPORATION, Osaka, JP;
Abstract
This invention provides compositions for use in distributing active agents for treating a malignant tumor in a subject. The compositions contain RNAi molecules targeted to a human GST-π, along with RNAi molecules targeted to a human p21, and a pharmaceutically acceptable carrier. The carrier can include nanoparticles composed of an ionizable lipid, a structural lipid, one or more stabilizer lipids, and a lipid for reducing immunogenicity of the nanoparticles. This invention further provides methods for preventing or treating a malignant tumor by administering a therapeutically effective amount of an RNAi composition.