The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Mar. 15, 2021

Filed:

Jan. 25, 2018
Applicants:

Biomarin Technologies B.v., Leiden, NL;

Academisch Ziekenhuis Leiden, Leiden, NL;

Inventors:
Assignees:
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C12N 15/113 (2009.12); A61K 31/56 (2005.12); A61K 31/57 (2005.12); A61K 31/573 (2005.12); A61K 31/58 (2005.12); A61K 31/7088 (2005.12); A61K 38/17 (2005.12); A61K 45/06 (2005.12); A61K 48/00 (2005.12);
U.S. Cl.
CPC ...
C12N 15/113 (2012.12); A61K 31/56 (2012.12); A61K 31/57 (2012.12); A61K 31/573 (2012.12); A61K 31/58 (2012.12); A61K 31/7088 (2012.12); A61K 38/1719 (2012.12); A61K 45/06 (2012.12); A61K 48/00 (2012.12); C12N 2310/11 (2012.12); C12N 2310/111 (2012.12); C12N 2310/31 (2012.12); C12N 2310/313 (2012.12); C12N 2310/314 (2012.12); C12N 2310/315 (2012.12); C12N 2310/3181 (2012.12); C12N 2310/321 (2012.12); C12N 2310/3231 (2012.12); C12N 2310/3233 (2012.12); C12N 2310/346 (2012.12); C12N 2320/31 (2012.12); C12N 2320/33 (2012.12);
Abstract

The invention provides means and methods for alleviating one or more symptom(s) of Duchenne Muscular Dystrophy and/or Becker Muscular Dystrophy. Therapies using compounds for providing patients with functional muscle proteins are combined with at least one adjunct compound for reducing inflammation, preferably for reducing muscle tissue inflammation, and/or at least one adjunct compound for improving muscle fiber function, integrity and/or survival.


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