The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Oct. 05, 2020

Filed:

Oct. 29, 2018
Applicant:

Genentech, Inc., South San Francisco, CA (US);

Inventors:

James John Crawford, San Francisco, CA (US);

Daniel Fred Ortwine, San Ramon, CA (US);

BinQing Wei, Belmont, CA (US);

Wendy B. Young, San Mateo, CA (US);

Assignee:

Genetech, Inc., South San Francisco, CA (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 487/04 (2005.12); A61P 37/00 (2005.12); A61P 35/00 (2005.12); A61K 9/20 (2005.12); A61K 31/495 (2005.12); A61K 31/496 (2005.12); A61K 31/4985 (2005.12); A61K 31/4995 (2005.12); A61K 31/501 (2005.12); A61K 31/5025 (2005.12); A61K 31/506 (2005.12); A61K 31/53 (2005.12); A61K 31/5377 (2005.12); A61K 31/5383 (2005.12); A61K 45/06 (2005.12); C07D 471/04 (2005.12); C07D 471/14 (2005.12); C07D 487/08 (2005.12); C07D 487/14 (2005.12); C07D 495/04 (2005.12); C07D 495/14 (2005.12); C07D 498/04 (2005.12); C07D 513/04 (2005.12); C07D 519/00 (2005.12);
U.S. Cl.
CPC ...
C07D 487/04 (2012.12); A61K 9/20 (2012.12); A61K 31/495 (2012.12); A61K 31/496 (2012.12); A61K 31/4985 (2012.12); A61K 31/4995 (2012.12); A61K 31/501 (2012.12); A61K 31/506 (2012.12); A61K 31/5025 (2012.12); A61K 31/53 (2012.12); A61K 31/5377 (2012.12); A61K 31/5383 (2012.12); A61K 45/06 (2012.12); A61P 35/00 (2017.12); A61P 37/00 (2017.12); C07D 471/04 (2012.12); C07D 471/14 (2012.12); C07D 487/08 (2012.12); C07D 487/14 (2012.12); C07D 495/04 (2012.12); C07D 495/14 (2012.12); C07D 498/04 (2012.12); C07D 513/04 (2012.12); C07D 519/00 (2012.12);
Abstract

Heteroaryl pyridone and aza-pyridone compounds of Formula I are provided, where one or two of X, X, and Xare N, and including stereoisomers, tautomers, and pharmaceutically acceptable salts thereof, useful for inhibiting Btk kinase, and for treating immune disorders such as inflammation mediated by Btk kinase. Methods of using compounds of Formula I for in vitro, in situ, and in vivo diagnosis, and treatment of such disorders in mammalian cells, or associated pathological conditions, are disclosed.


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