The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 16, 2019
Filed:
Nov. 03, 2016
Applicant:
Sanofi Pasteur Biologics Llc, Cambridge, MA (US);
Inventors:
Simon Delagrave, Stoneham, MA (US);
Rachid Oubelaid, Vitry-sur-Seine, FR;
John Hamberger, Milford, NJ (US);
Assignee:
Sanofi Pasteur Biologics LLC, Cambridge, MA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 15/86 (2005.12); C12N 5/00 (2005.12); C12N 7/00 (2005.12); C12N 15/63 (2005.12);
U.S. Cl.
CPC ...
C12N 7/00 (2012.12); C12N 5/0018 (2012.12); C12N 2500/34 (2012.12); C12N 2500/36 (2012.12); C12N 2500/76 (2012.12); C12N 2710/16051 (2012.12); C12N 2710/16052 (2012.12);
Abstract
The present invention relates to virus growth media that improve the yield of alpha-herpesviruses (e.g., HSV-2) grown in cell cultures. The growth media of the invention include two additives, a disaccharide and a lipid mixture, that can be added to serum-free or serum-enriched growth media to improve the efficiency of virus production. The invention further provides methods of producing alpha-herpesviruses (e.g., HSV-2) in such growth media.