The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 02, 2019
Filed:
Sep. 28, 2016
Applicant:
Nucana Plc, London, GB;
Inventor:
Christopher McGuigan, Peterson Super Ely, GB;
Assignee:
NuCana PLC, London, GB;
Primary Examiner:
Int. Cl.
CPC ...
A01N 43/04 (2005.12); A61K 31/70 (2005.12); C07H 19/04 (2005.12); C07H 19/10 (2005.12);
U.S. Cl.
CPC ...
C07H 19/10 (2012.12);
Abstract
Phosphoramidate derivatives of nucleotides and their use in the treatment of cancer are described. The base moieties of, for example, each of deoxyuridine, cytarabine, gemcitabine and citidine may be substituted at the 5-position. The phosphoramidate moiety has attached to the P atom an aryl-O moiety and an α-amino acid moiety. The α-amino acid moiety may correspond to or be derived from either a naturally occurring or a non-naturally occurring amino acid.