The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 01, 2019
Filed:
Mar. 25, 2016
Applicant:
Mucosis B.v., Groningen, NL;
Inventors:
Cornelis Alexander Maria de Haan, Utrecht, NL;
Petrus Josephus Marie Rottier, Utrecht, NL;
Bert Jan Haijema, Groningen, NL;
Assignee:
Mucosis B.V., Groningen, NL;
Primary Examiner:
Int. Cl.
CPC ...
A61K 39/155 (2005.12); C07K 14/005 (2005.12); C07K 19/00 (2005.12); A61K 39/12 (2005.12);
U.S. Cl.
CPC ...
A61K 39/155 (2012.12); A61K 39/12 (2012.12); C07K 14/005 (2012.12); C12N 2760/18511 (2012.12); C12N 2760/18534 (2012.12);
Abstract
Heat-stable oligomeric recombinant polypeptides, presenting at least one antigenic epitope of the pre-fusion Respiratory Syncytial Virus (RSV) F protein, comprising the RSV F protein ectodomain, functionally deleted in the HRB region, transmembrane and cytoplasmic domains replaced with a heterologous trimerization domain, and absent two functional multibasic furin cleavage sites, are useful as antigenic components in immunogenic compositions useful in methods of inducing an immune response and vaccinate against RSV infections.