The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 18, 2019
Filed:
Jun. 22, 2017
Applicant:
Onyx Therapeutics Inc., Thousand Oaks, CA (US);
Inventors:
Dustin McMinn, Pacifica, CA (US);
Henry Johnson, San Bruno, CA (US);
Simeon Bowers, Oakland, CA (US);
David C. Moebius, Foster City, CA (US);
Assignee:
ONYX THERAPEUTICS INC., Thousand Oaks, CA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07K 5/083 (2005.12); C07D 405/12 (2005.12); C07D 409/12 (2005.12); C07D 303/32 (2005.12); C07K 5/097 (2005.12); C07K 5/078 (2005.12); C07K 5/06 (2005.12); C07K 5/065 (2005.12); C07K 5/072 (2005.12); C07K 5/062 (2005.12); A61K 38/06 (2005.12);
U.S. Cl.
CPC ...
C07K 5/0821 (2012.12); A61K 38/06 (2012.12); C07K 5/06069 (2012.12); C07K 5/06078 (2012.12); C07K 5/06121 (2012.12); C07K 5/06147 (2012.12); C07K 5/06173 (2012.12); C07K 5/06191 (2012.12);
Abstract
Provided herein are tripeptide epoxy ketone protease inhibitors, methods of their preparation, related pharmaceutical compositions, and methods of using the same. For example, provided herein are compounds of Formula (X): and pharmaceutically acceptable salts and compositions including the same. The compounds and compositions provided herein may be used, for example, in the treatment of diseases including inflammation and neurodegenerative disease.