The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 05, 2017
Filed:
May. 13, 2015
Applicant:
Aerase, Inc., Austin, TX (US);
Inventors:
George Georgiou, Austin, TX (US);
Everett Stone, Austin, TX (US);
Assignee:
AERASE, INC., Austin, TX (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 38/46 (2005.12); C07H 21/04 (2005.12); C12N 9/78 (2005.12); C12N 9/14 (2005.12); C12N 9/96 (2005.12); A61K 38/50 (2005.12); A61K 47/48 (2005.12); A61K 38/00 (2005.12);
U.S. Cl.
CPC ...
A61K 38/50 (2012.12); A61K 47/48215 (2012.12); C12N 9/78 (2012.12); C12Y 305/03001 (2012.12); A61K 38/00 (2012.12);
Abstract
Compositions and methods for the treatment of cancer are described, and, more preferably, to the treatment of cancers that do not express, or are otherwise deficient in, argininosuccinate synthetase, with enzymes that deplete L-Arginine in serum. In one embodiment, the present invention contemplates an arginase protein, such as a human Arginase I protein, comprising at least one amino acid substitution and a metal cofactor, said protein comprising an increased catalytic activity when compared with a native human Arginase I.