The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 03, 2016
Filed:
Jun. 06, 2012
Applicants:
David A. Schwartz, Encinitas, CA (US);
Richard I. Hogrefe, San Diego, CA (US);
Inventors:
David A. Schwartz, Encinitas, CA (US);
Richard I. Hogrefe, San Diego, CA (US);
Assignee:
SOLULINK, INCORPORATED, San Diego, CA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07F 9/02 (2005.12); A61K 47/48 (2005.12); C04B 35/632 (2005.12); C07D 207/46 (2005.12); C07D 207/452 (2005.12); C07D 213/82 (2005.12); C07D 401/12 (2005.12); C07F 7/18 (2005.12); C07F 9/24 (2005.12); C07F 9/58 (2005.12); C07H 21/00 (2005.12);
U.S. Cl.
CPC ...
A61K 47/4823 (2012.12); A61K 47/48238 (2012.12); A61K 47/48284 (2012.12); A61K 47/48315 (2012.12); A61K 47/48376 (2012.12); C04B 35/632 (2012.12); C07D 207/452 (2012.12); C07D 207/46 (2012.12); C07D 213/82 (2012.12); C07D 401/12 (2012.12); C07F 7/1836 (2012.12); C07F 9/2408 (2012.12); C07F 9/588 (2012.12); C07H 21/00 (2012.12);
Abstract
Hydrazino, oxyamino and carbonyl-based reagents and methods for incorporation into oligonucleotides during their solid phase synthesis are provided. Modified oligonucleotides are provided that incorporate the reagents provided herein. Immobilized oligonucleotides and oligonucleotide conjugates that contain covalent hydrazone or oxime linkages are provided. Methods for preparation of surface bound oligonucleotides are provided. Methods for the preparation of oligonucleotide conjugates are also provided.