The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 03, 2014
Filed:
Mar. 04, 2010
Jonathan Gershoni, Herzylia, IL;
Erez Moshe Bublil, Holon, IL;
Dimitri Denisov, Hamilton, CA;
Galina Denisova, Hamilton, CA;
Jonathan Gershoni, Herzylia, IL;
Erez Moshe Bublil, Holon, IL;
Dimitri Denisov, Hamilton, CA;
Galina Denisova, Hamilton, CA;
Ramot at Tel-Aviv University Ltd., Tel Aviv, IL;
Abstract
The structure of conformational, discontinuous binding surfaces that associate with a binding molecule, preferably the epitopes of monoclonal antibodies (mAbs) may be discovered. The binding molecule is used to select specific peptides from a peptide library that, in turn, are used as a binding surface (epitope) defining database that is applied via a novel computer algorithm to analyze the crystalline-structure of the original binding surface (antigen). An antigenic epitope-mimetic that is recognized by its original mAb may be reconstituted based on the segments of the epitope identified in the prediction. The basic elements of the binding domain on gp120 that is recognized by broadly neutralizing antibody b12 are disclosed, as in their use in making vaccines for preventing or treating HIV.