The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 31, 2012
Filed:
Sep. 15, 1991
Scott David Gorman, Oxford, GB;
Michael Ronald Clark, Cambridge, GB;
Stephen Paul Cobbold, Oxford, GB;
Herman Waldmann, Oxford, GB;
Scott David Gorman, Oxford, GB;
Michael Ronald Clark, Cambridge, GB;
Stephen Paul Cobbold, Oxford, GB;
Herman Waldmann, Oxford, GB;
Glaxo Wellcome Inc. Research, Triangle Park, NC (US);
Abstract
An altered antibody chain is produced in which the CDR's of the variable domain of the chain are derived from a first mammalian species. The framework-encoding regions of DNA encoding the variable domain of the first species are mutated so that the mutated framework-encoding regions encode a framework derived from a second different mammalian species. The or each constant domain of the antibody chain, if present, are also derived from the second mammalian species.