The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 10, 2012
Filed:
Sep. 12, 2006
Tomio Kimura, Tokyo, JP;
Nobuyuki Ohkawa, Tokyo, JP;
Takayoshi Nagasaki, Tokyo, JP;
Atsuhiro Sugidachi, Tokyo, JP;
Osamu Ando, Tokyo, JP;
Tomio Kimura, Tokyo, JP;
Nobuyuki Ohkawa, Tokyo, JP;
Takayoshi Nagasaki, Tokyo, JP;
Atsuhiro Sugidachi, Tokyo, JP;
Osamu Ando, Tokyo, JP;
Daiichi Sankyo Company, Limited, Tokyo, JP;
Abstract
A compound of formula (I) Wherein X, Y, ring A, ring B, l, m, R, R, Rand Rare as defined herein, to supress intracellular signal transduction or cell activation induced by endotoxin and to suppress cell responses due to the intracellular signal transduction and cell activation such as an excess generation of inflammatory mediators such as TNF-α, pharmacologically acceptable salts therefor, a preparation method therefor, and a medicament containing the aforementioned substituted cycloalkene derivative as an active ingredient which is superior in prophylaxis and/or treatment of diseases such as sepsis (septic shock, disseminated intravascular coagulation, multiple organ failure and the like), that are associated with intracellular signal transduction or cell activation induced by endotoxin and to cell responses to the intracellular signal transduction and cell activation.