The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 22, 2009
Filed:
Oct. 25, 2005
Jean-paul Renë Marie Andrë Bosmans, Rijkevorsel, BE;
Michel Anna Jozef Decleyn, Merksplas, BE;
Michel Surkyn, Kessel-lo, BE;
Jean-Paul Renë Marie Andrë Bosmans, Rijkevorsel, BE;
Michel Anna Jozef DeCleyn, Merksplas, BE;
Michel Surkyn, Kessel-lo, BE;
Janssen Pharmaceutica, N.V., Beerse, BE;
Abstract
The present invention of compounds of formula (I)a stereochemically isomeric form thereof, an N-oxide form thereof or a pharmaceutically acceptable acid addition salt thereof, Rand Rtaken together form a bivalent radical of formula wherein in said bivalent radicals one or two hydrogen atoms may be substituted with Calkyl; Ris hydrogen or halo; Ris hydrogen or Calkyl; Ris hydrogen or Calkyl; L is Ccycloalkyl, Ccycloalkanone, Calkenyl, or L is a radical of formula —Alk—R—, Alk—X—R, —Alk—Y—C(═O)—R, or —Alk—Y—C (═O)—NRRwherein each Alk is Calkanediyl; and Ris hydrogen, cyano, Calkylsulfonylamino, Ccycloalkyl, Ccycloalkanone, or a heterocyclic ring-system; Ris hydrogen, Calkyl, hydroxyCalkyl, Ccycloalkyl, or a heterocyclic ringsystem; X is O, SOor NR; said Rbeing hydrogen or Calkyl; Ris hydrogen, Calkyl, Ccycloalkyl, Calkyloxy or hydroxy; Y is NRor a direct bond; said Rbeing hydrogen, or Calkyl; Rand Reach independently are hydrogen, Calkyl, Ccycloalkyl, or Rand Rcombined with the nitrogen atom may form an optionally substituted pyrrolidinyl, piperidinyl, piperazinyl or 4-morpholinyl ring. Processes for preparing said products, formulations comprising said products and their use as a medicine are disclosed, in particular for treating conditions which are related to impairment of gastric emptying.