The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 15, 2007
Filed:
May. 24, 1998
Montserrant Monsalvatje Llagostera, Barcelona, ES;
Marti Bartra Sanmarti, Barcelona, ES;
Jaime Thomas Navarro, Barcelona, ES;
Salvador Puig Torres, Barcelona, ES;
Montserrant Monsalvatje Llagostera, Barcelona, ES;
Marti Bartra Sanmarti, Barcelona, ES;
Jaime Thomas Navarro, Barcelona, ES;
Salvador Puig Torres, Barcelona, ES;
Esteve Quimica, S.A., Barcelona, ES;
Abstract
The process for obtaining quinapril hydrochloride (I) comprises the stages of: a) hydrogenolysis of the benzyl ester of quinapril (II) by treatment in an alcoholic solvent, with concentrated hydrochloric acid or a solution of hydrogen chloride in isopropanol, and hydrogenation; b) removal of the solvent; c) addition of toluene to precipitate the quinapril hydrochloride as a toluene solvate; d) treatment of said solvate with a Class 3 solvent which forms a solvate of quinapril hydrochloride from which it can be removed by drying without degrading; and e) drying of the solvate from step d) to yield quinapril hydrochloride (I), an antihypertensive agent.