The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 02, 2007
Filed:
Jan. 22, 2003
Amarpreet S. Sawhney, Lexington, MA (US);
Peter K. Jarrett, Sudbury, MA (US);
Arthur J. Coury, Boston, MA (US);
Ronald S. Rudowsky, Sudbury, MA (US);
Michelle D. Lyman, Peabody, MA (US);
Luis Z. Avila, Arlington, MA (US);
David J. Enscore, Sudbury, MA (US);
Stephen D. Goodrich, Tucson, AZ (US);
William C. Nason, Groton, MA (US);
Fei Yao, N. Andover, MA (US);
Douglas Weaver, Bedford, MA (US);
Shikha P. Barman, Bedford, MA (US);
Amarpreet S. Sawhney, Lexington, MA (US);
Peter K. Jarrett, Sudbury, MA (US);
Arthur J. Coury, Boston, MA (US);
Ronald S. Rudowsky, Sudbury, MA (US);
Michelle D. Lyman, Peabody, MA (US);
Luis Z. Avila, Arlington, MA (US);
David J. Enscore, Sudbury, MA (US);
Stephen D. Goodrich, Tucson, AZ (US);
William C. Nason, Groton, MA (US);
Fei Yao, N. Andover, MA (US);
Douglas Weaver, Bedford, MA (US);
Shikha P. Barman, Bedford, MA (US);
Genzyme Corporation, Cambridge, MA (US);
Abstract
Water-soluble macromers including at least one hydrolysable linkage formed from carbonate or dioxanone groups, at least one water-soluble polymeric block, and at least one polymerizable group, and methods of preparation and use thereof are described. The macromers are preferably polymerized using free radical initiators under the influence of long wavelength ultraviolet light or visible light excitation. Biodegradation occurs at the linkages within the extension oligomers and results in fragments which are non-toxic and easily removed from the body. The macromers can be used to encapsulate cells, deliver prophylactic, therapeutic or diagnostic agents in a controlled manner, plug leaks in tissue, prevent adhesion formation after surgical procedures, temporarily protect or separate tissue surfaces, and adhere or seal tissues together.