The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 06, 2006
Filed:
Mar. 21, 2004
Jih-hua Liu, Green Oaks, IL (US);
George A. Foster, Jr., Minden, NV (US);
Stephen H. Montgomery, Vernon Hills, IL (US);
Jih-Hua Liu, Green Oaks, IL (US);
George A. Foster, Jr., Minden, NV (US);
Stephen H. Montgomery, Vernon Hills, IL (US);
Abbott Laboratories, Abbott Park, IL (US);
Abstract
A procedure for preparing 6-O-alkyl erythromycin compounds having the formula:wherein Ris a loweralkyl group, Rand Ran independently hydrogen or a hydroxy-protecting group, except that Rand Rmay not both be hydrogen simultaneously; Y is oxygen or a specifically substituted oxime; and Z is hydrogen, hydroxy or protected-hydroxy; by reaction of the compound wherein Ris hydrogen with an alkylating reagent, is the presence of a strong alkali metal base and also in the presence of a weak organic amino base, in a suitable stirred or agitated polar aprotic solvent, or a mixture of such polar aprotic solvents maintained at a reaction temperature and for a period of time sufficient to effect alkyation.