The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 16, 2006
Filed:
Feb. 10, 2005
Wen Sen LI, Holmdel, NJ (US);
John E. Thornton, Newtown, PA (US);
Zhenrong Guo, East Brunswick, NJ (US);
Shankar Swaminathan, Monmouth Junction, NJ (US);
Robert M. Borzilleri, New Hope, PA (US);
Soong-hoon Kim, Titusville, NJ (US);
Denis Favreau, St. Hubert, CA;
Wen Sen Li, Holmdel, NJ (US);
John E. Thornton, Newtown, PA (US);
Zhenrong Guo, East Brunswick, NJ (US);
Shankar Swaminathan, Monmouth Junction, NJ (US);
Robert M. Borzilleri, New Hope, PA (US);
Soong-Hoon Kim, Titusville, NJ (US);
Denis Favreau, St. Hubert, CA;
Bristol-Myers Squibb Co., Princeton, NJ (US);
Abstract
The present invention relates to a process for the preparation of epothilone analogs by initially forming novel ring-opened epothilones and carrying out a macrolactamization reaction thereon. The subject process is amenable to being carried out in a single reaction vessel without isolation of the intermediate compound and provides at least about a three-fold increase in yield over prior processes for preparing the desired epothilone analogs.