The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Dec. 05, 2005

Filed:

Nov. 17, 1999
Applicants:

Bert Vogelstein, Baltimore, MD (US);

Kenneth W. Kinzler, Bel Air, MD (US);

Hans Albertsen, Salt Lake City, UT (US);

Rakesh Anand, Chelford, GB;

Mary Carlson, Salt Lake City, UT (US);

Joanna Groden, Cincinnati, OH (US);

Philip John Hedge, Goostrey, GB;

Geoff Joslyn, Fremont, CA (US);

Alexander Fred Markham, Crewe, GB;

Yusuka Nakamura, Tokyo, JP;

Andrew Thilveris, Madison, WI (US);

Raymond L. White, Tiburon, CA (US);

Inventors:

Bert Vogelstein, Baltimore, MD (US);

Kenneth W. Kinzler, Bel Air, MD (US);

Hans Albertsen, Salt Lake City, UT (US);

Rakesh Anand, Chelford, GB;

Mary Carlson, Salt Lake City, UT (US);

Joanna Groden, Cincinnati, OH (US);

Philip John Hedge, Goostrey, GB;

Geoff Joslyn, Fremont, CA (US);

Alexander Fred Markham, Crewe, GB;

Yusuka Nakamura, Tokyo, JP;

Andrew Thilveris, Madison, WI (US);

Raymond L. White, Tiburon, CA (US);

Assignees:

The Johns Hopkins University, Baltimore, MD (US);

The University of Utah, Salt Lake City, UT (US);

The Cancer Institute, Tokyo, JP;

Zeneca Limited, London, GB;

Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C07K016/32 ; C12N005/12 ; C12N015/12 ;
U.S. Cl.
CPC ...
Abstract

A human gene termed APC is disclosed. Methods and kits are provided for assessing mutations of the APC gene in human tissues and body samples. APC mutations are found in familial adenomatous polyposis patients as well as in sporadic colorectal cancer patients. APC is expressed in most normal tissues. These results suggest that APC is a tumor suppressor.


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