The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 21, 2021
Filed:
Dec. 20, 2019
David Austin Roses Ltd., Wolverhampton, GB;
David J. C. Austin, Wolverhampton, GB;
David Austin Roses Ltd., Albrighton, GB;
Abstract
An optical biomodule for detecting a disease specific biomarker(s), utilizing enhanced fluorescence emission (due to integration of a three-dimensional (3-D) protruded structure(s)) in a fluidic container/zero-mode waveguide, upon chemical binding of a disease specific biomarker(s) with its corresponding disease specific biomarker binder(s) is disclosed. The three-dimensional (3-D) protruded structure(s) can be coupled with a photonic crystal and/or a metamaterial and/or a metamaterial of Epsilon-Near-Zero (ENZ) of a suitable wavelength range. Furthermore, the enhanced fluorescence emission can be modulated by a synthetic Cas13 protein coupled with a CRISPR RNA (crRNA) and a quenched fluorescent reporter. Alternatively, a suitable synthetic substitute of a synthetic Cas13 protein coupled with a CRISPR RNA (crRNA) containing variable targeting sequence can also be utilized.