The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 19, 2018
Filed:
Aug. 29, 2016
Applicant:
Visen Medical, Inc., Waltham, MA (US);
Inventors:
Milind Rajopadhye, Westford, MA (US);
Kevin Groves, Arlington, MA (US);
Dorin V. Preda, Medford, MA (US);
Assignee:
VisEn Medical, Inc., Waltham, MA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 38/00 (2006.01); A61K 49/00 (2006.01); C09B 23/01 (2006.01); C09B 23/08 (2006.01); C07K 5/11 (2006.01); C07K 7/06 (2006.01); C07K 7/64 (2006.01); A61K 47/65 (2017.01);
U.S. Cl.
CPC ...
A61K 49/0032 (2013.01); A61K 47/65 (2017.08); A61K 49/0056 (2013.01); C07K 5/1019 (2013.01); C07K 7/06 (2013.01); C07K 7/64 (2013.01); C09B 23/0008 (2013.01); C09B 23/083 (2013.01); C09B 23/086 (2013.01);
Abstract
Provided is a family of intramolecularly quenched imaging agents for use in both in vivo and in vitro imaging that contain at least one enzymatically cleavable oligopeptide and two fluorophores or a fluorophore and a quencher. When subjected to proteolytic cleavage, at least one fluorophore is unquenched and becomes capable of producing a fluorescent signal upon excitation with light of an appropriate wavelength. Also provided are in vivo and in vitro imaging methods using such imaging agents.