The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jun. 19, 2018

Filed:

Apr. 08, 2015
Applicant:

Children's Hospital Medical Center, Cincinnati, OH (US);

Inventors:

Bruce J. Aronow, Cincinnati, OH (US);

John B. Harley, Cincinnati, OH (US);

Margaret Hostetter, Cincinnati, OH (US);

Kenneth Kaufman, Cincinnati, OH (US);

Assignee:

Children's Hospital Medical Center, Cincinnati, OH (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12Q 1/68 (2018.01); C07H 21/04 (2006.01); A61K 38/14 (2006.01); A61K 31/7036 (2006.01);
U.S. Cl.
CPC ...
A61K 38/14 (2013.01); A61K 31/7036 (2013.01); C12Q 1/6883 (2013.01); C12Q 2600/156 (2013.01);
Abstract

Disclosed are methods for identifying patients at increased risk of developing disseminated staphylococcal infection, which includes the steps of determining that the patient has a mutation in one or more genes selected from a MPDZ network gene, a CGNL1 network gene, a PRKRIR network gene, a MED26 network gene, a tight junction protein gene, or an immune modulator gene; and treating the patient for disseminated staphylococcal infection. Also disclosed are solid substrates and/or assays useful for carrying out the disclosed methods.


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