The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 19, 2018
Filed:
May. 01, 2015
Femtogenix Limited, Welwyn Garden City, GB;
David Edwin Thurston, London, GB;
Khondaker Mirazur Rahman, London, GB;
Paul Joseph Mark Jackson, London, GB;
Femtogenix Limited, London, GB;
Abstract
The invention relates to pyrrolo[2,1-c][1,4]benzodiazepines (PBDs) of formula (I) and in particular to PBD dimers linked through the C1 position, and PBD monomers linked through the C1 position to aromatic groups, and pharmaceutically acceptable salts thereof, which are useful as medicaments, in particular as anti-proliferative agents. (I) and salts or solvates thereof, wherein: the dotted lines indicates the optional presence of a double bond between C1 and C2 or C2 and C3; R-Rare independently selected substituent groups; and either: (i) Rand Rtogether form a double bond; (ii) Ris H and Ris OH; or (iii) Ris H and Ris ORand Ris Calkyl; where Rhas the formula: -X-L-X'-D-X-L-X′- is a linker group and D has the formula (II) or (III): or where the compound is a dimer with each monomer being the same or different and being of formula (I) where the Rof the first monomer and R′or R′of the second monomer, or Rof the first monomer and R′of the second monomer, form together a bridge having the formula -X-L-X′- linking the monomers.