The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 19, 2018
Filed:
Jun. 17, 2016
Applicant:
Duke University, Durham, NC (US);
Inventors:
Donald P. McDonnell, Chapel Hill, NC (US);
Daniel Frigo, Houston, TX (US);
Anthony R. Means, Boerne, TX (US);
Assignee:
Duke University, Durham, NC (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 471/04 (2006.01); C07K 16/40 (2006.01); A61K 31/4745 (2006.01); C12Q 1/48 (2006.01); C12Q 1/68 (2018.01); G01N 33/574 (2006.01); A61K 31/437 (2006.01); A61K 31/7088 (2006.01); G01N 33/68 (2006.01); C07K 16/30 (2006.01); C12N 15/113 (2010.01);
U.S. Cl.
CPC ...
A61K 31/4745 (2013.01); A61K 31/437 (2013.01); A61K 31/7088 (2013.01); C07K 16/3069 (2013.01); C07K 16/40 (2013.01); C12N 15/1137 (2013.01); C12Q 1/485 (2013.01); C12Q 1/6886 (2013.01); C12Y 207/11017 (2013.01); G01N 33/57434 (2013.01); G01N 33/6893 (2013.01); C07K 2317/76 (2013.01); C12N 2310/14 (2013.01); C12N 2320/30 (2013.01); C12Q 2600/106 (2013.01); C12Q 2600/112 (2013.01); C12Q 2600/136 (2013.01); C12Q 2600/158 (2013.01); G01N 2333/912 (2013.01); G01N 2500/04 (2013.01); G01N 2500/10 (2013.01); G01N 2500/20 (2013.01); G01N 2800/52 (2013.01);
Abstract
Provided herein are compounds, compositions, including pharmaceutical compositions, having anti-cancer activity. Also provided are methods for diagnosing, detecting, and treating cancer in a subject, as well as a method for evaluating cancer stage in a subject, wherein the methods include determining the amount of a Ca/calmodulin dependent kinase kinase (CaMKK) in a sample. Further provided are methods of screening and identifying a compound that inhibits CaMKK.