The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 12, 2018
Filed:
Jun. 12, 2015
Applicant:
The Regents of the University of California, Oakland, CA (US);
Inventors:
Charles L. Sawyers, New York, NY (US);
Mercedes E. Gorre, New York, NY (US);
Neil Pravin Shah, Mill Valley, CA (US);
John Nicoll, Sylmar, CA (US);
Assignee:
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, Oakland, CA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12Q 1/68 (2018.01); G01N 33/574 (2006.01); C07K 14/82 (2006.01); C12Q 1/48 (2006.01);
U.S. Cl.
CPC ...
C12Q 1/6886 (2013.01); C07K 14/82 (2013.01); C12Q 1/485 (2013.01); G01N 33/5748 (2013.01); C12Q 2600/106 (2013.01); C12Q 2600/136 (2013.01); C12Q 2600/156 (2013.01); G01N 2333/912 (2013.01); G01N 2500/10 (2013.01); G01N 2800/52 (2013.01);
Abstract
The invention described herein relates to novel genes and their encoded proteins, termed Mutants Associated with Resistance to STI-571 (e.g., T315I Bu-Abl), and to diagnostic and therapeutic methods and compositions useful in the management of various cancers that express MARS. The invention further provides methods for identifying molecules that bind to and/or modulate the functional activity of MARS.