The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 12, 2018
Filed:
Apr. 24, 2015
Applicants:
Brown University, Providence, RI (US);
Yale University, New Haven, CT (US);
Inventors:
Jack A. Elias, Providence, RI (US);
Yang Zhou, Providence, RI (US);
Chun Geun Lee, Providence, RI (US);
Assignees:
Brown University, Providence, RI (US);
Yale University, New Haven, CT (US);
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/00 (2006.01); C12Q 1/68 (2018.01); G01N 33/573 (2006.01);
U.S. Cl.
CPC ...
C12Q 1/6883 (2013.01); A61K 31/00 (2013.01); C12Y 302/01014 (2013.01); G01N 33/573 (2013.01); C12Q 2600/158 (2013.01); G01N 2333/924 (2013.01); G01N 2800/12 (2013.01);
Abstract
Described herein are methods, assays, and systems related to the prognosis, diagnosis, and treatment of Hermansky Pudlak Syndrome (HPS) and, e.g., pulmonary fibrosis in a subject. As described herein, subjects with HPS who have, will develop, or are most at risk or developing pulmonary fibrosis have elevated levels of CHI3L1. In some embodiments, the methods comprise administering an agonist of IL-13Rα2 or an inhibitor of CRTH2 to the subject.