The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 12, 2018
Filed:
May. 30, 2013
Applicant:
Lanzatech New Zealand Limited, Auckland, NZ;
Inventors:
Michael Koepke, Auckland, NZ;
Wendy Yiting Chen, Auckland, NZ;
Assignee:
LanzaTech New Zealand Limited, Auckland, NZ;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12P 7/52 (2006.01); C12R 1/145 (2006.01); C12N 9/02 (2006.01); C12P 7/42 (2006.01);
U.S. Cl.
CPC ...
C12P 7/52 (2013.01); C12N 9/0008 (2013.01); C12P 7/42 (2013.01); C12R 1/145 (2013.01); C12Y 102/01075 (2013.01);
Abstract
Bacteria are genetically engineered to produce 3-hydroxypropionate (3-HP). The bacteria are carboxydotrophic acetogens. The bacteria produce acetyl-coA using the Wood-Ljungdahl pathway for fixing CO/CO. A malonyl-coA reductase from a bacterium that contains such an enzyme is introduced. Additionally, an acetyl-coA carboxylase may also be introduced The production of 3-HP can be improved by overproduction of acetyl-CoA carboxylase or by overproduction of biotin. This can be effected by improved promoters or higher copy number or enzymes that are catalytically more efficient.