The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 12, 2018
Filed:
Aug. 11, 2015
Applicant:
The Trustees of the University of Pennsylvania, Philadelphia, PA (US);
Inventors:
James L. Riley, Downingtown, PA (US);
Chrystal Paulos, Philadelphia, PA (US);
Carl H. June, Merion Station, PA (US);
Bruce L. Levine, Cherry Hill, NJ (US);
Assignee:
THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA, Philadelphia, PA (US);
Primary Examiner:
Int. Cl.
CPC ...
A61K 35/26 (2015.01); C12N 5/0783 (2010.01); A61K 35/17 (2015.01); A61K 39/00 (2006.01);
U.S. Cl.
CPC ...
C12N 5/0637 (2013.01); A61K 35/17 (2013.01); C12N 5/0636 (2013.01); A61K 2039/5158 (2013.01); A61K 2039/57 (2013.01); C12N 2501/2301 (2013.01); C12N 2501/2302 (2013.01); C12N 2501/2306 (2013.01); C12N 2501/2321 (2013.01); C12N 2501/2323 (2013.01); C12N 2501/51 (2013.01); C12N 2501/515 (2013.01); C12N 2501/599 (2013.01);
Abstract
The invention includes compositions and methods for generating and expanding therapeutic Th17 cells. The invention includes contacting T cells with a composition comprising a first agent that is capable of providing a primary activation signal to T cells and a second agent that is capable of activating ICOS on T cells in the presence of Th-17 polarizing agents.