The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 12, 2018
Filed:
Jun. 01, 2017
Zymogenetics, Inc., Princeton, NJ (US);
Zeren Gao, Redmond, WA (US);
Steven D. Levin, Seattle, WA (US);
Janine M. Bilsborough, Simi Valley, CA (US);
James W. West, San Mateo, CA (US);
Cameron S. Brandt, Seattle, WA (US);
Eric M. Chadwick, Bellevue, WA (US);
Bristol-Myers Squibb Company, Princeton, NJ (US);
Abstract
The present invention provides a newly identified B7 receptor, zB7R1 that functions as lymphocyte inhibitory receptor, which is a PD-1-like molecule and is expressed on T cells. The present invention also provides the discovery of zB7R1's ability to bind to CD155. Methods and compositions for modulating zB7R1-mediated negative signaling and interfering with the interaction of its counter-receptor for therapeutic, diagnostic and research purposes are also provided.