The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 12, 2018
Filed:
Feb. 19, 2013
Massachusetts Institute of Technology, Cambridge, MA (US);
The Children's Medical Center Corporation, Boston, MA (US);
Robert S. Langer, Newton, MA (US);
Daniel G. Anderson, Sudbiry, MA (US);
Zhen Gu, Cambridge, MA (US);
Alex Arthur Aimetti, Waltham, MA (US);
Massachusetts Institute of Technology, Cambridge, MA (US);
The Children's Medical Center Corporation, Boston, MA (US);
Abstract
A glucose binding amphiphilic peptide hydrogel insulin delivery system that is responsive to glucose concentrations under physiological conditions is provided. Insulin is encapsulated in a glucose binding hydrogel, made from self-assembling amphiphilic peptides including a hydrophobic domain including a beta sheet forming region coupled to a charged hydrophilic domain modified to contain a glucose binding segment. The formulations are designed to release insulin as a function of blood glucose level, maintaining the patients' blood glucose level in an optimum range and avoiding both hyper- and hypoglycemia.