The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 12, 2018
Filed:
Jun. 11, 2015
Merck Sharp & Dohme Corp., Rahway, NJ (US);
Kenneth Leavitt, Mount Laurel, NJ (US);
Brendan Crowley, Collegeville, PA (US);
Ian M. Bell, Harleysville, PA (US);
Andrew Harvey, Thebarton, AU;
Thomas Avery, Thebarton, AU;
Dharam Paul, Thebarton, AU;
Justin Ripper, Thebarton, AU;
Belinda Huff, Thebarton, AU;
Rajinder Singh, Thebarton, AU;
Laurent Schaeffer, Illkirch, FR;
Christophe Joseph, Illkirch, FR;
Christophe Morice, Illkirch, FR;
Bruno Giethlen, Illkirch, FR;
Patrick Bazzini, Illkirch, FR;
Aurelie Fromeyer, Illkirch, FR;
MERCK SHARP & DOHME CORP., Rahway, NJ (US);
Abstract
Disclosed are compounds of Formula (IVA), or a salt thereof, and pharmaceutical formulations (pharmaceutical compositions) comprising those compounds, or a salt thereof: Formula (IVA), wherein 'R', 'R', “R”, “R”, “R”, are defined herein above, which compounds are believed suitable for use in positive modulation of the alpha 7 nicotinic acetylcholine receptor (α7 nAChR) receptors, for example, those found in the cerebral cortex and the hippocampus. Such compounds and pharmaceutical formulations are believed to be useful in treatment or management of neurodegenerative diseases, for example, Alzheimer's disease (AD), schizophrenia, and Parkinson's disease (PD), or movement disorders arising from use of certain medications used in the treatment or management of Parkinson's disease.