The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jun. 12, 2018

Filed:

Mar. 02, 2016
Applicant:

Muffin Incorporated, West Lafayette, IN (US);

Inventors:

Shelley Lynn Scoville, Athens, GA (US);

Amanda F. Taylor, West Lafayette, IN (US);

Steven Charlebois, West Lafayette, IN (US);

Christine M. Steinhart, Ramona, CA (US);

Neal E. Fearnot, West Lafayette, IN (US);

Assignee:

Muffin Incorporated, West Lafayette, IN (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07K 9/00 (2006.01); A61L 27/36 (2006.01); A61L 27/54 (2006.01); A61L 27/12 (2006.01);
U.S. Cl.
CPC ...
A61L 27/3633 (2013.01); A61L 27/12 (2013.01); A61L 27/54 (2013.01); A61L 2300/414 (2013.01); A61L 2400/06 (2013.01); A61L 2430/02 (2013.01);
Abstract

Osteogenic compositions include a decellularized extracellular matrix tissue and bone morphogenic protein, preferably BMP-2. The compositions make beneficial use of the BMP, which can be used at relatively low doses and can bind to native components (e.g., native sulfated glycosaminoglycans such as heparin and/or heparan sulfate) remaining in the decellularized extracellular matrix tissue. Methods for preparation and use of such compositions are also described. The compositions and related methods can be used in the treatment of diseased or damaged bone tissue.


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