The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 12, 2018
Filed:
Jul. 09, 2015
Applicant:
Quark Pharmaceuticals, Inc., Fremont, CA (US);
Inventor:
Elena Feinstein, Rehovot, IL;
Assignee:
Quark Pharmaceuticals, Inc., Fremont, CA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 39/395 (2006.01); A61K 39/44 (2006.01); C07K 16/30 (2006.01); C07K 16/28 (2006.01); A61K 47/48 (2006.01); A61K 49/00 (2006.01); A61K 47/68 (2017.01);
U.S. Cl.
CPC ...
A61K 47/48561 (2013.01); A61K 39/39541 (2013.01); A61K 39/39558 (2013.01); A61K 49/0058 (2013.01); C07K 16/2851 (2013.01); A61K 47/6849 (2017.08); C07K 2317/56 (2013.01); C07K 2317/565 (2013.01); C07K 2317/622 (2013.01); C07K 2317/77 (2013.01); C07K 2317/92 (2013.01);
Abstract
The present invention provides antibodies or antigen-binding fragments thereof that specifically bind the ENDO180 polypeptide and are internalized thereby, to conjugates comprising the molecules, to compositions comprising the antibodies and conjugates and to methods of using the same for delivery of therapeutic agents to cells that express the ENDO180 polypeptide on the surface of the cell for treating cell proliferative diseases or disorders and fibrosis, and for controlling (modulating) tumor progression.